Fig. 1

Study design. We simulated two different therapy regimens (study arms). The standard arm contains a single induction therapy using the 7 + 3 regimen (7 days cytarabine + 3 days anthracycline). After the induction the course of the leukemia is observed without further intervention. The evaluation arm contains one or two additional bone marrow (BM) evaluations. Based on the blasts abundance (%) a second induction consisting of a 5 + 2 protocol can be given. Patients with blast clearance will be observed without further intervention